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Three Pool Model of Calcium Signaling

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Author: Hariprasad, Daniel
Advisor: Shi, Junping
Committee Members: Lewis, Robert Michael; Smith, Gregory D.; Tian, Jianjun Paul
Issued Date: 2009-05-08
Subjects: Dynamical Systems
Molecular biology
URI: http://hdl.handle.net/10288/1179
Description: Mitochondria have been proposed to be an integral part of intracellular calcium signaling. We examine the two-pool model of intracellular calcium signaling by Goldbeter et al. 1990 [11] and propose a new model that uses the mitochondria. This creates a three-pool model for intracellular calcium signaling. We then proceed to discuss the differences between the two-pool and three-pool models by following the analysis of the two-pool model presented by Sneyd et al. 1993 [19]. The addition of the third pool does not change any of the dynamics of the two-pool model, but adds some functionality. The mitochondria acts like a buffer that has the ability to change the temporal dynamics, and we have a region of bistability that allows for dampened oscillations given the right stimulus and initial conditions.
Degree: Bachelors of Science in Mathematics


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