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Spontaneous Amide Bond Formation of Amino Acids in Aqueous Solution

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Author: Milam, Sarah Joan
Advisor: Kranbuehl, David E.
Committee Members: Abelt, Christopher John, 1956-; Bagdassarian, Carey; Whitley, Kim
Issued Date: 2009-05-13
Subjects: Polymer chemistry
Amino acid
Abiogenic
Proteinoid
Peptide bonds
URI: http://hdl.handle.net/10288/1207
Description: Previous studies in Dr. Kranbuehl's laboratory at the College of William and Mary have shown that carboxylic acids and amines react spontaneously to form amides. These results prompted questions about whether amino acids, which possess both carboxylic acid and amine functionality, would also spontaneously form amide bonds, creating peptides. For this study, aqueous amino acid solutions were created and placed in a 120�C oven. Samples were taken over time and analyzed both quantitatively with a gas chromatograph mass spectrometer and qualitatively with an ion trap mass spectrometer. This dual analysis method allows for the measurement of amino acid concentration and the detection of small quantities of polypeptides.
Degree: Bachelors of Science in Chemistry


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