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Synthesis of 1-(5-methylhexyl)-2,3,8,9-tetrahydro-1H-naphtho[2,1-e]indol-6(7H)-one

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Author: Lopez, Nicholas
Advisor: Abelt, Christopher J.
Committee Members: Landino, Lisa M.; Westberg, Christine
Issued Date: 5/5/2011
Subjects: Cholesterol
Fluorescence
Organic Compounds
Synthesis
URI: http://hdl.handle.net/10288/13663
Description: The goal of study was to explore the synthesis of 1-(5-methylhexyl)-2,3,8,9-tetrahydro-1H-naphtho[2,1-e]indol-6(7H)-one. This molecule is designed to act as a fluorescent model for cholesterol. It mimics cholesterol in terms of size, shape, and hydrophobic nature. . A nine-step synthesis was explored in order to develop this model. 1-(5-methylhexyl)-2,3,8,9-tetrahydro-1H-naphtho[2,1-e]indol-6(7H)-one was designed to be used as a cholesterol model in order to explore the cholesterol binding sites of the protein human serum albumin.
Degree: Bachelors of Science in Chemistry


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