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Modeling synaptic facilitation and depression in thalamocortical relay cells

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Author: Walch, Olivia J.
Advisor: Smith, Gregory D.
Committee Members: Griffin, John D.; Shaw, Leah B.
Issued Date: 5/14/2011
Subjects: Biology
Applied mathematics
URI: http://hdl.handle.net/10288/13735
Description: Thalamocortical relay (TC) neurons in the lateral geniculate nucleus receive both retinal and cortical input; however, the two pre-synaptic signals are filtered in significantly different ways. Using a three-compartment model of a TC cell, with distinct equations for the proximal and distal dendrites, we model the synaptic plasticity of feedback signals from the cortex (corticogeniculate facilitation) and feedforward retinal input (retinogeniculate depression). We discuss the use of model-generated cross-correlograms in lending insight into the interplay of the driving and modulating afferents.
Degree: Bachelors of Science in Interdisciplinary Studies

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