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Synthesis of 1-(6-(dimethylamino)naphthalen-2-yl)-2,2-dimethylpropan-1-one as a Fluorescent Probe of Solvent Acidity in HSA

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Author: Green, Amy Michele
Advisor: Abelt, Christopher J.
Committee Members: Tian, Jianjun Paul; Poutsma, John C.
Issued Date: 7/17/2012
Subjects: HSA
Solvent acidity
URI: http://hdl.handle.net/10288/16766
Description: The goal of this study was to synthesize 1-(6-(dimethylamino)naphthalen-2-yl)-2,2-dimethylpropan-1-one, a PRODAN derivative, and perform fluorescence studies comparing the efficacy of various PRODAN derivatives as probes of solvent acidity in HSA. Fluorescence and absorption studies were performed to calculate relative quantum yields of probe-HSA complexes to free probe. Using the relationship between relative quantum yield and solvent acidity, the microacidity in HSA was extrapolated. 3-(dimethylamino)-8,9,10,11-tetrahydro-7H-cyclohepta[a] naphthalen -7-one was determined to be the optimal probe in this study.
Degree: Bachelors of Science in Chemistry

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