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Investigations of the Fragmentation Spectra of Heptapeptides Containing Lysine and its Non-Protein Amino Acid Homologs

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Author: Challener, Douglas William
Advisor: Poutsma, John C.
Committee Members: Landino, Lisa M.; Rice, Gary; Tian, Jianjun Paul
Issued Date: 2010-05-11
Subjects: Peptides
Lysine
Fragmentation
URI: http://hdl.handle.net/10288/1938
Description: The goal of this experiment was to determine if trends exist in the fragmentation pat- terns of heptapeptides containing lysine and its non-protein amino acid analogs (or- nithine, daba, dapa). Previous research in the laboratory of Dr. J. C. Poutsma on pentapeptides suggested that the length of the side chain on the lysine analog played a role in peptide fragmentation pathways. This study, however, found no such connection between length of side chain and fragmentation patterns suggesting that as a peptide lengthens the flexibility of the peptide bonds outweigh the side chain length factor in determining fragmentation patterns.
Degree: Bachelors of Science in Chemistry


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